Bone marrow is a spongy substance that is found in the center of the bone. It produces bone marrow stem cells and other components, which are then converted into blood cell. Stem cells ate special cells that can make copies of themselves and changes into any kind of blood cells.
A bone marrow transplant is a procedure that infuses healthy forming stem cells into your body to replace your diseased bone marrow. Nowadays hematopoietic stem cells can also be obtained from peripheral blood after treatment with growth factors.
What are the symptoms of bone marrow issues ?
There are issues with stem cells or how they form in patients with bone marrow diseases: The bone marrow procedure aberrant white blood cells in leukemia, a type of blood cancer dysplastic or infective or synthesis decreased synthesis of stem cells in aplastic anaemia.
The bone marrow makes too many white blood cells in mylopeoliferative disorders. Bone marrow issue includes symptoms like:
Shortness of breath.
Frequent or prolonged infections.
Unexplained or easy bruising.
Nosebleeds and bleeding gums.
Prolonged bleeding from cuts.
Unexplained weight loss.
Drenching night sweats.
Bone marrow transplant can benefit people with a variety of both cancerous or non cancerous (begin)Disease including
Thalassemia / sickle cell anemia
Bone marrow failure syndrome
Types of bone marrow transplant
Types of bone marrow transplant include:
Autologous transplant: To replenish bone marrow, people obtain stems cells from their own.Patient’s own stem cells
are used and infused after relevant treatment.
Allogenic transplant: This is done using donor’s stem cells after HLA matching, generally a sibling but can be unrelated done, Matched unrelated donor transplant - In this transplant HLA matched stem cells are btained from a unrelated donor who is normally identified through stem cell registry.
Haploidentical transplantation: This is a therapy option for about 70% of persons who do not have an HLA-identical matching donor.It is type of allogenic transplant done with partially matched donor. Donor is usually a direct sbood relative like Mother/ Father/ Brother/ Sister/ Son/ Daughter.
Umbilical cord blood (a type of allogeneic transplant): A healthcare worker extracts stem cells from a newborn baby’s umbilical cord shortly after birth (a sort of allogeneic transplant).The stem cells are frozen and stored until they are needed for a transplant. Due to the immaturity of umbilical cord blood cells, there is less of a need for matching, although blood counts take significantly longer.